About Us

Direct lineage reprogramming is the process of converting somatic cells directly into other lineages without passing through a pluripotent intermediate state. Unlike these methods that rely on induced pluripotent stem cells, this technique bypasses the intermediate stage, making the process faster and potentially safer.

The process relies on the introduction of specific transcription factors or chemical agents. These factors "reprogram" the cell's identity, allowing it to adopt the characteristics and functions of the target cell type. For example, fibroblasts can be directly converted into neurons, insulin-producing beta cells, or even heart cells.

Direct lineage reprogramming holds immense promise in regenerative medicine. Its ability to directly convert cells into clinically valuable types offers hope for innovative treatments and therapies.

CRT is Stand Up Therapeutics' proprietary technology designed to "reset" dysfunctional cells, restoring them toward a pre-disease state. It leverages cellular master regulators that govern physiological gene-expression programs and epigenetic homeostasis, re-establishing native identity and function.

This approach moves beyond conventional treatments that merely supplement deficient proteins, instead aiming for the functional recovery of the cell itself. In neurodegenerative disorders like Parkinson's disease, CRT offers the potential to reactivate dysfunctional dopaminergic neurons, thereby halting disease progression and offering a path toward a fundamental cure.